Neuroscience brings a wealth of highly significant findings into the world that help us understand how we are generically designed as human beings. Research of the brain and nervous system provides deep insight into how our inner operating system is built, and gives us both tools and confidence in our capacities to change and heal.

Neuroscience shows that our brain remains malleable and adaptive throughout our whole life. This
neural plasticity allows for our human brain to grow new neurons and synaptic connections, and to establish new neural circuits. Whenever the structures of our synaptic network change, the resulting functions change as well.

Unlike the program-controlled brains of worms, snails, and insects, and unlike the initially programmable brains of birds and mammals, the human brain is a program-opening social construction, capable of re-programming itself throughout a lifetime. Due to the
prefrontal cortex - the part of the brain that is uniquely human - we are beings that can re-program the very program that makes us up. This self-directed neuroplasticity is the prevalent and most notable feature of our 'human design'.

Interpersonal Neurobiology in particular emphasizes that the development of our brain during all of our life is nourished, shaped and matured by mindful, empathic
relationships. We operate from a social brain, i.e. we are designed to live in connection. We regulate each other, and we provide each other with the opportunities to grow and change. It is in this shelter of each other that we human beings live.

The specific contribution of neuroscience to
- the
operating principles which govern the 99,9% of our imprint that are generically human, especially our self-directed neuroplasticity and our social brain, ie. Our design to co-regulate each other's brains and states,
- the relevance of the imprint mapped out by the Human Design System, as a mere starting point in the development of a
sense of self, and a unique set of challenges, to be met in transcending the personal separate sense of self,
- the heavy emphasis on
left hemisphere approach (resulting in a certain, fixed, explicit, abstract, generalized, de-personalised, de-contextualized re-presentation) in the original Human Design System, and the need for balance and juxtaposition with a right hemisphere approach to do a human being justice,
- the
option of choice, and the pathways to transformation that are deeply embedded in our biological 'hardware' and 'software',
- the importance and indispensability of personal contact and
empathic relationship in our work with people, to truly support them on their journey to Essence, and in the embodiment of their greatness.

Research shows that the majority of our genes are expressed in the brain. The genetic program furnishes the brain with the anatomy of its various areas and transmitter systems. However, it does not preset any neural circuits for specific patterns of interpretation and response. The imprint derived from the Human Design System can thus be seen as a unique personal illusion of mind, which when reified holds one captured in the mechanics of the
Maya (Maia, illusion), rather than an organic predetermination.

Once we grasp how constructing one's Self is deeply rooted in neural plasticity, the
personal self becomes transparent as an ever-changing interface. From this perspective, it gets much easier for us to transcend this construction altogether, and find our way back to Essence - where wisdom and compassion are expressions of our true nature. Higher consciousness emerges through us as we recognize ourselves being one with the boundless field of awareness - without getting lost in it, or overly attached to the personal self.